Can Skin Exposure to Sunlight Prevent Liver Inflammation?
AbstractLiver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation. View Full-Text
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Gorman, S.; Black, L.J.; Feelisch, M.; Hart, P.H.; Weller, R. Can Skin Exposure to Sunlight Prevent Liver Inflammation? Nutrients 2015, 7, 3219-3239.
Gorman S, Black LJ, Feelisch M, Hart PH, Weller R. Can Skin Exposure to Sunlight Prevent Liver Inflammation? Nutrients. 2015; 7(5):3219-3239.Chicago/Turabian Style
Gorman, Shelley; Black, Lucinda J.; Feelisch, Martin; Hart, Prue H.; Weller, Richard. 2015. "Can Skin Exposure to Sunlight Prevent Liver Inflammation?" Nutrients 7, no. 5: 3219-3239.