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Nutrients 2014, 6(10), 4002-4031; doi:10.3390/nu6104002

Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis

1
Food Nutrition & Health, Food & Bio-based Products, AgResearch Grasslands, Private Bag 11008, Tennent Drive, Palmerston North 4442, New Zealand
2
Institute for Cell & Molecular Biosciences, University of Newcastle upon Tyne, Newcastle NE2 4HH, UK
3
Bioinformatics & Statistics AgResearch Grasslands, Private Bag 11008, Tennent Drive, Palmerston North 4442, New Zealand
4
Riddet Institute, Massey University, Palmerston North 4442, New Zealand
5
Gravida: National Centre for Growth and Development, the University of Auckland, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 20 August 2014 / Accepted: 21 August 2014 / Published: 29 September 2014
(This article belongs to the Special Issue Nutritional Epigenetics)
View Full-Text   |   Download PDF [501 KB, uploaded 29 September 2014]

Abstract

Selenium may play a beneficial role in multi-factorial illnesses with genetic and environmental linkages via epigenetic regulation in part via glutathione peroxidase (GPx) activity. A meta-analysis was undertaken to quantify the effects of dietary selenium supplementation on the activity of overall GPx activity in different tissues and animal species and to compare the effectiveness of different forms of dietary selenium. GPx activity response was affected by both the dose and form of selenium (p < 0.001). There were differences between tissues on the effects of selenium supplementation on GPx activity (p < 0.001); however, there was no evidence in the data of differences between animal species (p = 0.95). The interactions between dose and tissue, animal species and form were significant (p < 0.001). Tissues particularly sensitive to changes in selenium supply include red blood cells, kidney and muscle. The meta-analysis identified that for animal species selenium-enriched foods were more effective than selenomethionine at increasing GPx activity. View Full-Text
Keywords: dietary selenium supplementation; glutathione peroxidase activity; meta-analysis; selenium; epigenetic regulation dietary selenium supplementation; glutathione peroxidase activity; meta-analysis; selenium; epigenetic regulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bermingham, E.N.; Hesketh, J.E.; Sinclair, B.R.; Koolaard, J.P.; Roy, N.C. Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis. Nutrients 2014, 6, 4002-4031.

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