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Protection of Dietary Polyphenols against Oral Cancer
Department of Stomatology, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
* Authors to whom correspondence should be addressed.
Received: 1 March 2013; in revised form: 24 April 2013 / Accepted: 28 May 2013 / Published: 14 June 2013
Abstract: Oral cancer represents a health burden worldwide with approximate 275,000 new cases diagnosed annually. Its poor prognosis is due to local tumor invasion and frequent lymph node metastasis. Better understanding and development of novel treatments and chemo-preventive approaches for the preventive and therapeutic intervention of this type of cancer are necessary. Recent development of dietary polyphenols as cancer preventives and therapeutic agents is of great interest due to their antioxidant and anti-carcinogenic activities. Polyphenols may inhibit carcinogenesis in the stage of initiation, promotion, or progression. In particular, dietary polyphenols decrease incidence of carcinomas and exert protection against oral cancer by induction of cell death and inhibition of tumor growth, invasion, and metastasis. In this review, we discuss current progress of dietary polyphenols against oral cancers in vitro, in vivo, and at population levels.
Keywords: dietary polyphenols; tea polyphenols; (−)-epigallocatechin-3-gallate; oral cancer; cancer prevention; cancer therapy; cell death; cell growth; cell migration and invasion
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Cite This Article
MDPI and ACS Style
Ding, Y.; Yao, H.; Yao, Y.; Fai, L.Y.; Zhang, Z. Protection of Dietary Polyphenols against Oral Cancer. Nutrients 2013, 5, 2173-2191.
Ding Y, Yao H, Yao Y, Fai LY, Zhang Z. Protection of Dietary Polyphenols against Oral Cancer. Nutrients. 2013; 5(6):2173-2191.
Ding, Yijian; Yao, Hua; Yao, Yanan; Fai, Leonard Y.; Zhang, Zhuo. 2013. "Protection of Dietary Polyphenols against Oral Cancer." Nutrients 5, no. 6: 2173-2191.