Nutrients 2013, 5(6), 2144-2172; doi:10.3390/nu5062144
Article

Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome

1 Obesity and Metabolic Health Division, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, UK 2 Biomathematics and Statistics Scotland, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, AB21 9SB, UK
* Author to whom correspondence should be addressed.
Received: 6 March 2013; in revised form: 6 May 2013 / Accepted: 28 May 2013 / Published: 10 June 2013
(This article belongs to the Special Issue Dietary Fiber and Nutrition)
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Abstract: This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (−11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%–83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.
Keywords: insulin sensitivity; stable isotope kinetics; non-starch polysaccharides; resistant starch; weight loss; Minimal Models; metabolic syndrome

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MDPI and ACS Style

Lobley, G.E.; Holtrop, G.; Bremner, D.M.; Calder, A.G.; Milne, E.; Johnstone, A.M. Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome. Nutrients 2013, 5, 2144-2172.

AMA Style

Lobley GE, Holtrop G, Bremner DM, Calder AG, Milne E, Johnstone AM. Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome. Nutrients. 2013; 5(6):2144-2172.

Chicago/Turabian Style

Lobley, Gerald E.; Holtrop, Grietje; Bremner, David M.; Calder, A. G.; Milne, Eric; Johnstone, Alexandra M. 2013. "Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome." Nutrients 5, no. 6: 2144-2172.

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