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Nutrients 2013, 5(6), 2144-2172; doi:10.3390/nu5062144
Article

Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome

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Received: 6 March 2013; in revised form: 6 May 2013 / Accepted: 28 May 2013 / Published: 10 June 2013
(This article belongs to the Special Issue Dietary Fiber and Nutrition)
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Abstract: This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (−11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%–83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS.
Keywords: insulin sensitivity; stable isotope kinetics; non-starch polysaccharides; resistant starch; weight loss; Minimal Models; metabolic syndrome insulin sensitivity; stable isotope kinetics; non-starch polysaccharides; resistant starch; weight loss; Minimal Models; metabolic syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lobley, G.E.; Holtrop, G.; Bremner, D.M.; Calder, A.G.; Milne, E.; Johnstone, A.M. Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome. Nutrients 2013, 5, 2144-2172.

AMA Style

Lobley GE, Holtrop G, Bremner DM, Calder AG, Milne E, Johnstone AM. Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome. Nutrients. 2013; 5(6):2144-2172.

Chicago/Turabian Style

Lobley, Gerald E.; Holtrop, Grietje; Bremner, David M.; Calder, A. G.; Milne, Eric; Johnstone, Alexandra M. 2013. "Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome." Nutrients 5, no. 6: 2144-2172.


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