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Nutrients 2013, 5(2), 498-508; doi:10.3390/nu5020498
Review

Fat Depots, Free Fatty Acids, and Dyslipidemia

1
 and 2,*
Received: 31 December 2012; in revised form: 31 January 2013 / Accepted: 4 February 2013 / Published: 7 February 2013
(This article belongs to the Special Issue Dyslipidemia and Obesity)
Download PDF [411 KB, uploaded 7 February 2013]
Abstract: Body fat deposition and excess free fatty acid (FFA) metabolism contribute to dyslipidemia and the adverse health consequences of obesity. Individuals with upper body obesity have impaired functioning of adipocytes, the primary fatty acid storage site. Excess visceral fat is strongly associated with impaired suppression of FFA release in response to insulin, as well as with hypertriglyceridemia and low concentrations of high density lipoprotein (HDL) cholesterol. High FFA concentrations can induce insulin resistance in muscle and liver. Furthermore, failure of hyperinsulinemia to normally suppress FFA is associated with impaired carbohydrate oxidation and muscle glucose storage, reduced hepatic insulin clearance and elevated triglycerides. Understanding the impact of body fat distribution on FFA metabolism and dyslipidemia is critical for determining the link between overweight and obesity and cardiovascular disease risk. In the current review, we will explore the relationship between adipose tissue, body fat depots, and FFA metabolism.
Keywords: free fatty acid; fat depots; dyslipidemia free fatty acid; fat depots; dyslipidemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ebbert, J.O.; Jensen, M.D. Fat Depots, Free Fatty Acids, and Dyslipidemia. Nutrients 2013, 5, 498-508.

AMA Style

Ebbert JO, Jensen MD. Fat Depots, Free Fatty Acids, and Dyslipidemia. Nutrients. 2013; 5(2):498-508.

Chicago/Turabian Style

Ebbert, Jon O.; Jensen, Michael D. 2013. "Fat Depots, Free Fatty Acids, and Dyslipidemia." Nutrients 5, no. 2: 498-508.


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