Next Article in Journal
Do Fat Supplements Increase Physical Performance?
Next Article in Special Issue
Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches
Previous Article in Journal
Brain Enhancing Ingredients from Āyurvedic Medicine: Quintessential Example of Bacopa monniera, a Narrative Review
Nutrients 2013, 5(2), 498-508; doi:10.3390/nu5020498
Review

Fat Depots, Free Fatty Acids, and Dyslipidemia

1
 and
2,*
Received: 31 December 2012 / Revised: 31 January 2013 / Accepted: 4 February 2013 / Published: 7 February 2013
(This article belongs to the Special Issue Dyslipidemia and Obesity)
Download PDF [411 KB, uploaded 7 February 2013]

Abstract

Body fat deposition and excess free fatty acid (FFA) metabolism contribute to dyslipidemia and the adverse health consequences of obesity. Individuals with upper body obesity have impaired functioning of adipocytes, the primary fatty acid storage site. Excess visceral fat is strongly associated with impaired suppression of FFA release in response to insulin, as well as with hypertriglyceridemia and low concentrations of high density lipoprotein (HDL) cholesterol. High FFA concentrations can induce insulin resistance in muscle and liver. Furthermore, failure of hyperinsulinemia to normally suppress FFA is associated with impaired carbohydrate oxidation and muscle glucose storage, reduced hepatic insulin clearance and elevated triglycerides. Understanding the impact of body fat distribution on FFA metabolism and dyslipidemia is critical for determining the link between overweight and obesity and cardiovascular disease risk. In the current review, we will explore the relationship between adipose tissue, body fat depots, and FFA metabolism.
Keywords: free fatty acid; fat depots; dyslipidemia free fatty acid; fat depots; dyslipidemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Ebbert, J.O.; Jensen, M.D. Fat Depots, Free Fatty Acids, and Dyslipidemia. Nutrients 2013, 5, 498-508.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert