Next Article in Journal
Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review
Next Article in Special Issue
A Retrospective Investigation of Thiamin and Energy Intakes Following an Outbreak of Beriberi in the Gambia
Previous Article in Journal
Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea
Previous Article in Special Issue
Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis
Article Menu

Export Article

Open AccessReview
Nutrients 2010, 2(7), 693-724; doi:10.3390/nu2070693

Vitamin D and Bone Health; Potential Mechanisms

School of Biomedical Sciences, University of Ulster, Coleraine, UK
Author to whom correspondence should be addressed.
Received: 5 June 2010 / Revised: 22 June 2010 / Accepted: 29 June 2010 / Published: 5 July 2010
(This article belongs to the Special Issue Feature Papers for Vitamins)
View Full-Text   |   Download PDF [256 KB, uploaded 5 July 2010]   |  


Osteoporosis is associated with increased morbidity, mortality and significant economic and health costs. Vitamin D is a secosteriod hormone essential for calcium absorption and bone mineralization which is positively associated with bone mineral density [BMD]. It is well-established that prolonged and severe vitamin D deficiency leads to rickets in children and osteomalacia in adults. Sub-optimal vitamin D status has been reported in many populations but it is a particular concern in older people; thus there is clearly a need for effective strategies to optimise bone health. A number of recent studies have suggested that the role of vitamin D in preventing fractures may be via its mediating effects on muscle function (a defect in muscle function is one of the classical signs of rickets) and inflammation. Studies have demonstrated that vitamin D supplementation can improve muscle strength which in turn contributes to a decrease in incidence of falls, one of the largest contributors to fracture incidence. Osteoporosis is often considered to be an inflammatory condition and pro-inflammatory cytokines have been associated with increased bone metabolism. The immunoregulatory mechanisms of vitamin D may thus modulate the effect of these cytokines on bone health and subsequent fracture risk. Vitamin D, therefore, may influence fracture risk via a number of different mechanisms.
Keywords: vitamin D; bone; fracture bone mineral density; muscle strength; cytokines vitamin D; bone; fracture bone mineral density; muscle strength; cytokines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Laird, E.; Ward, M.; McSorley, E.; Strain, J.; Wallace, J. Vitamin D and Bone Health; Potential Mechanisms. Nutrients 2010, 2, 693-724.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top