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Nutrients 2010, 2(5), 532-550; doi:10.3390/nu2050532
Review

Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis

Received: 25 March 2010; in revised form: 7 May 2010 / Accepted: 18 May 2010 / Published: 25 May 2010
(This article belongs to the Special Issue Feature Papers for Vitamins)
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Abstract: Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the experimental models used, the vitamin A-deficient avian embryo has been an important tool to study the function of vitamin A during early heart formation. A cluster of retinoic acid-regulated developmental genes have been identified that participate in building the heart. In the absence of retinoic acid the embryonic heart develops abnormally leading to embryolethality.
Keywords: vitamin A-deficient; quail embryo; retinoic acid; gene regulation; heart morphogenesis vitamin A-deficient; quail embryo; retinoic acid; gene regulation; heart morphogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zile, M.H. Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis. Nutrients 2010, 2, 532-550.

AMA Style

Zile MH. Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis. Nutrients. 2010; 2(5):532-550.

Chicago/Turabian Style

Zile, Maija H. 2010. "Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis." Nutrients 2, no. 5: 532-550.


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