Nutrients 2010, 2(7), 725-736; doi:10.3390/nu2070725
Review

Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review

email and * email
Received: 24 May 2010; in revised form: 2 July 2010 / Accepted: 5 July 2010 / Published: 7 July 2010
(This article belongs to the Special Issue Dietary Antioxidants)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.
Keywords: antioxidant; reactive oxygen species (ROS); atherosclerosis; conjugated linoleic acid (CLA); vitamin E (or α-tocopherol); peroxisome proliferator-activated receptor gamma (PPARγ); nuclear factor kappa B (NF-κB)
PDF Full-text Download PDF Full-Text [96 KB, uploaded 7 July 2010 11:14 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Nakamura, Y.K.; Omaye, S.T. Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review. Nutrients 2010, 2, 725-736.

AMA Style

Nakamura YK, Omaye ST. Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review. Nutrients. 2010; 2(7):725-736.

Chicago/Turabian Style

Nakamura, Yukiko K.; Omaye, Stanley T. 2010. "Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review." Nutrients 2, no. 7: 725-736.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert