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Nutrients 2010, 2(7), 683-692; doi:10.3390/nu2070683
Article

Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea

1,* , 2
, 3
, 4
 and 5
Received: 17 May 2010; in revised form: 18 June 2010 / Accepted: 21 June 2010 / Published: 30 June 2010
(This article belongs to the Special Issue Paediatric Nutrition and Metabolism)
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Abstract: We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9–24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course.
Keywords: diarrhea; infants; prebiotics; galacto-oligosaccharides; fructo-oligosaccharides; galacturonic oligosaccharides; cytokines diarrhea; infants; prebiotics; galacto-oligosaccharides; fructo-oligosaccharides; galacturonic oligosaccharides; cytokines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vaisman, N.; Press, J.; Leibovitz, E.; Boehm, G.; Barak, V. Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea. Nutrients 2010, 2, 683-692.

AMA Style

Vaisman N, Press J, Leibovitz E, Boehm G, Barak V. Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea. Nutrients. 2010; 2(7):683-692.

Chicago/Turabian Style

Vaisman, Nachum; Press, Josef; Leibovitz, Eugene; Boehm, Güenther; Barak, Vivian. 2010. "Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea." Nutrients 2, no. 7: 683-692.



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