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Nonclassical Vitamin D Actions
Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany
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Received: 23 February 2010; in revised form: 17 March 2010 / Accepted: 22 March 2010 / Published: 25 March 2010
Abstract: It is becoming increasingly clear that vitamin D has a broad range of actions in the human body. Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Vitamin D deficiency/insufficiency has been associated with muscle weakness and a high incidence of various chronic diseases such as cardiovascular disease, cancer, multiple sclerosis, and type 1 and 2 diabetes. Most importantly, low vitamin D status has been found to be an independent predictor of all-cause mortality. Several recent randomized controlled trials support the assumption that vitamin D can improve muscle strength, glucose homeostasis, and cardiovascular risk markers. In addition, vitamin D may reduce cancer incidence and elevated blood pressure. Since the prevalence of vitamin D deficiency/insufficiency is high throughout the world, there is a need to improve vitamin D status in the general adult population. However, the currently recommended daily vitamin D intake of 5–15 µg is too low to achieve an adequate vitamin D status in individuals with only modest skin synthesis. Thus, there is a need to recommend a vitamin D intake that is effective for achieving adequate circulating 25-hydroxyvitamin D concentrations (>75 nmol/L).
Keywords: vitamin D; cancer; cardiovascular; mortality; ultraviolet B radiation; diet
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Zittermann, A.; Gummert, J.F. Nonclassical Vitamin D Actions. Nutrients 2010, 2, 408-425.
Zittermann A, Gummert JF. Nonclassical Vitamin D Actions. Nutrients. 2010; 2(4):408-425.
Zittermann, Armin; Gummert, Jan F. 2010. "Nonclassical Vitamin D Actions." Nutrients 2, no. 4: 408-425.