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Nutrients 2010, 2(4), 426-437; doi:10.3390/nu2040426

Vitamin D and Cardiovascular Disease

Nutrition Department, School of Public Health, Sao Paulo University, Av. Dr. Arnaldo, 715, Cerqueira César, CEP 01246-904, São Paulo, Brazil
* Author to whom correspondence should be addressed.
Received: 26 January 2010 / Revised: 15 March 2010 / Accepted: 19 March 2010 / Published: 31 March 2010
(This article belongs to the Special Issue Feature Papers for Vitamins)
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Vitamin D insufficiency/deficiency has been observed worldwide at all stages of life. It has been characterized as a public health problem, since low concentrations of this vitamin have been linked to the pathogenesis of several chronic diseases. Several studies have suggested that vitamin D is involved in cardiovascular diseases and have provided evidence that it has a role in reducing cardiovascular disease risk. It may be involved in regulation of gene expression through the presence of vitamin D receptors in various cells, regulation of blood pressure (through renin-angiotensin system), and modulation of cell growth and proliferation including vascular smooth muscle cells and cardiomyocytes. Identifying correct mechanisms and relationships between vitamin D and such diseases could be important in relation to patient care and healthcare policies.
Keywords: vitamin D; cardiovascular disease; hypertension vitamin D; cardiovascular disease; hypertension
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Garcia, V.C.; Martini, L.A. Vitamin D and Cardiovascular Disease. Nutrients 2010, 2, 426-437.

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