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Nutrients 2010, 2(2), 128-170; doi:10.3390/nu2020128
Review

Oiling the Brain: A Review of Randomized Controlled Trials of Omega-3 Fatty Acids in Psychopathology across the Lifespan

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Received: 3 December 2009 / Accepted: 3 February 2010 / Published: 9 February 2010
(This article belongs to the Special Issue Omega-3 Update)
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Abstract

Around one in four people suffer from mental illness at some stage in their lifetime. There is increasing awareness of the importance of nutrition, particularly omega-3 polyunsaturated fatty acids (n-3 PUFA), for optimal brain development and function. Hence in recent decades, researchers have explored effects of n-3 PUFA on mental health problems over the lifespan, from developmental disorders in childhood, to depression, aggression, and schizophrenia in adulthood, and cognitive decline, dementia and Alzheimer’s disease in late adulthood. This review provides an updated overview of the published and the registered clinical trials that investigate effects of n-3 PUFA supplementation on mental health and behavior, highlighting methodological differences and issues.
Keywords: omega-3 polyunsaturated fatty acids; mental health; attention deficit hyperactivity disorder; autism; aggression; depression; dementia omega-3 polyunsaturated fatty acids; mental health; attention deficit hyperactivity disorder; autism; aggression; depression; dementia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sinn, N.; Milte, C.; Howe, P.R.C. Oiling the Brain: A Review of Randomized Controlled Trials of Omega-3 Fatty Acids in Psychopathology across the Lifespan. Nutrients 2010, 2, 128-170.

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