Nutrients 2010, 2(2), 116-127; doi:10.3390/nu2020116
Article

Dietary Phospholipids and Intestinal Cholesterol Absorption

Jeffrey S. Cohn* email, Alvin Kamiliemail, Elaine Watemail, Rosanna W. S. Chungemail and Sally Tandyemail
Nutrition and Metabolism Group, Heart Research Institute, 7 Eliza St. Newtown 2042 NSW, Sydney, Australia
* Author to whom correspondence should be addressed.
Received: 27 November 2009 / Accepted: 29 January 2010 / Published: 8 February 2010
(This article belongs to the Special Issue Phospholipid Nutrition)
PDF Full-text Download PDF Full-Text [176 KB, uploaded 8 February 2010 09:30 CET]
Abstract: Experiments carried out with cultured cells and in experimental animals have consistently shown that phospholipids (PLs) can inhibit intestinal cholesterol absorption. Limited evidence from clinical studies suggests that dietary PL supplementation has a similar effect in man. A number of biological mechanisms have been proposed in order to explain how PL in the gut lumen is able to affect cholesterol uptake by the gut mucosa. Further research is however required to establish whether the ability of PLs to inhibit cholesterol absorption is of therapeutic benefit.
Keywords: cardiovascular disease; cholesterol; intestine; micelle; phosphatidylcholine; phosphatidylethanolamine; phospholipid; sphingomyelin

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Cohn, J.S.; Kamili, A.; Wat, E.; Chung, R.W.S.; Tandy, S. Dietary Phospholipids and Intestinal Cholesterol Absorption. Nutrients 2010, 2, 116-127.

AMA Style

Cohn JS, Kamili A, Wat E, Chung RWS, Tandy S. Dietary Phospholipids and Intestinal Cholesterol Absorption. Nutrients. 2010; 2(2):116-127.

Chicago/Turabian Style

Cohn, Jeffrey S.; Kamili, Alvin; Wat, Elaine; Chung, Rosanna W. S.; Tandy, Sally. 2010. "Dietary Phospholipids and Intestinal Cholesterol Absorption." Nutrients 2, no. 2: 116-127.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert