Next Article in Journal
Pretreatment of Mice with Oligonucleotide prop5 Protects Them from Influenza Virus Infections
Next Article in Special Issue
CD81-Receptor Associations — Impact for Hepatitis C Virus Entry and Antiviral Therapies
Previous Article in Journal
Prevalence of Antibodies against Hantaviruses in Serum and Saliva of Adults Living or Working on Farms in Yorkshire, United Kingdom
Viruses 2014, 6(2), 535-572; doi:10.3390/v6020535

CD81 and Hepatitis C Virus (HCV) Infection

1 Center for Infection and Immunity of Lille, CNRS-UMR8204, Inserm-U1019, Institut Pasteur de Lille, Université Lille Nord de France, Institut de Biologie de Lille, 1 rue du Pr Calmette, CS50447, 59021 Lille Cedex, France 2 Department of Medicine, Division of Oncology, CCSR, Stanford University Medical Center, Stanford, CA 94305, USA
* Author to whom correspondence should be addressed.
Received: 24 December 2013 / Revised: 29 January 2014 / Accepted: 2 February 2014 / Published: 6 February 2014
(This article belongs to the Special Issue Viruses and Tetraspanins)
View Full-Text   |   Download PDF [2782 KB, uploaded 12 May 2015]   |   Browse Figures


Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped RNA virus mainly targeting liver cells and for which the initiation of infection occurs through a complex multistep process involving a series of specific cellular entry factors. This process is likely mediated through the formation of a tightly orchestrated complex of HCV entry factors at the plasma membrane. Among HCV entry factors, the tetraspanin CD81 is one of the best characterized and it is undoubtedly a key player in the HCV lifecycle. In this review, we detail the current knowledge on the involvement of CD81 in the HCV lifecycle, as well as in the immune response to HCV infection.
Keywords: Hepatitis C Virus; CD81; tetraspanins; entry factors; viral lifecycle; immune response Hepatitis C Virus; CD81; tetraspanins; entry factors; viral lifecycle; immune response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Fénéant, L.; Levy, S.; Cocquerel, L. CD81 and Hepatitis C Virus (HCV) Infection. Viruses 2014, 6, 535-572.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert