Special Issue "Viruses and Tetraspanins"
Deadline for manuscript submissions: 31 December 2013
Prof. Dr. Markus Thali
Microbiology and Molecular Genetics Department, University of Vermont, Stafford Hall, Rm 320, Burlington, VT 05405, USA
Phone: +1 802 656 1056
Tetraspanins control membrane-based processes such as cell-cell adhesion, migration, and fusion of cellular membranes. Not all that surprisingly, then, members of this family of integral membrane proteins have been implicated in the replication of various viruses. These include, among others, retroviruses (e.g. HIV-1 and HTLV), or HCV, the etiological agent for hepatitis C, for which the tetraspanin CD81 (together with other cell-surface molecules) has been shown to be critical for viral entry.
For this special issue of Viruses, we seek reports on research that will elucidate how exactly specific tetraspanins control discrete steps of viral life cycles. It is our hope that, together, these articles will further our understanding of how these molecular scaffolds regulate the interplay between viruses and their hosts.
Prof. Dr. Markus Thali
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Hepatitis C Virus Lifecycle and the Tetraspanin CD81
Authors: Laurence Cocquerel and Lucie Fénéant
Affiliation: Hepatitis C Laboratory, Center for Infection and Immunity of Lille, University Lille Nord de France, CNRS-UMR8204, Inserm-U1019, Pasteur Institute of Lille, 1 rue du Pr Calmette, BP447, 59021 Lille, France.; (L.C.) E-mail: email@example.com
Abstract: Hepatitis C Virus (HCV) infection is a global public health problem affecting over 130 million individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped RNA virus mainly targeting liver cells by a mechanism that has yet to be elucidated. HCV entry is a complex multistep process involving a series of specific cellular entry factors and is likely mediated through the formation of a tightly orchestrated HCV-entry factor complex at the plasma membrane. Among HCV entry factors, the tetraspanin CD81 is the best characterized and it has been shown as a key player in HCV lifecycle. In this review, we summarize the current knowledge on the role of CD81, tetraspanin-enriched microdomains and CD81-associated partners during HCV infection.
Type of Paper: Review
Title: Tetraspanin-co-receptor Association - Impact for HCV Entry and Antiviral Therapies
Authors: Laetitia Zona 1,2,#, Rajiv G. Tawar 1,2,#, Mirjam B. Zeisel 1,2, Fei Xiao 1,2, Catherine Schuster 1,2, Joachim Lupberger 1,2 and Thomas F. Baumert 1,2,3,*
1 Inserm, U1110, Strasbourg, France
2 University of Strasbourg, Strasbourg, France
3 Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France ; * Author to whom correspondence should be addressed: Thomas F. Baumert, M. D., Inserm U1110, Université de Strasbourg, 3 Rue Koeberlé, F-67000 Strasbourg, France ; E-Mail: Thomas.Baumert@unistra.fr, Tel.: (++33) 3 68 85 37 03; Fax: (++33) 3 68 85 37 24.
Abstract: Tetraspanins are integral transmembrane proteins that are widely expressed in different tissues. They are implicated in regulating membrane protein trafficking and membrane associated functions like adhesion and fusion via formation of tetraspanin-enriched microdomains (TEMs). Among tetraspanins, CD81 has been implicated in a variety of physiological and pathological processes. CD81 also plays a crucial role in pathogen infection, particularly in hepatitis C virus (HCV) entry. HCV is a major cause of liver cirrhosis and hepatocellular carcinoma. HCV entry into hepatocytes is a highly sophisticated process that requires the coordinated interaction of viral and host factors for the initiation of infection. CD81-claudin-1 (CLDN1) co-receptor complex formation is a key step within the HCV entry process. Recent data suggests that this co-receptor complex associates with other tetraspanin-associated proteins, particularly GTPase HRas, through which it modulates HCV entry. This review summarizes our understanding of the regulatory role of the tetraspanin co-receptor complex association in HCV entry into target cells and highlights its potential as therapeutic targets to prevent and treat HCV infection.
Keywords: Antivirals; Claudin-1; kinases; liver; transplantation
Last update: 18 November 2013