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CD81 and Hepatitis C Virus (HCV) Infection
Viruses 2014, 6(2), 875-892; doi:10.3390/v6020875

CD81-Receptor Associations — Impact for Hepatitis C Virus Entry and Antiviral Therapies

1 Inserm, U1110, 67000 Strasbourg, France 2 University of Strasbourg, 67000 Strasbourg, France 3 Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 3 December 2013 / Revised: 12 February 2014 / Accepted: 13 February 2014 / Published: 18 February 2014
(This article belongs to the Special Issue Viruses and Tetraspanins)
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Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners. Among them, CD81 has been implicated in a variety of physiological and pathological processes. CD81 also plays a crucial role in pathogen entry into host cells, including hepatitis C virus (HCV) entry into hepatocytes. HCV is a major cause of liver cirrhosis and hepatocellular carcinoma. HCV entry into hepatocytes is a complex process that requires the coordinated interaction of viral and host factors for the initiation of infection, including CD81, scavenger receptor BI, claudin-1, occludin, membrane-bound host cell kinases, Niemann-Pick C1 Like 1, Harvey rat sarcoma viral oncogene homolog (HRas), CD63 and transferrin receptor 1. Furthermore, recent data in HCV model systems have demonstrated that targeting critical components of tetraspanins and associated cell membrane proteins open new avenues to prevent and treat viral infection.
Keywords: antivirals; claudin-1; kinases; liver; transplantation antivirals; claudin-1; kinases; liver; transplantation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zona, L.; Tawar, R.G.; Zeisel, M.B.; Xiao, F.; Schuster, C.; Lupberger, J.; Baumert, T.F. CD81-Receptor Associations — Impact for Hepatitis C Virus Entry and Antiviral Therapies. Viruses 2014, 6, 875-892.

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