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Viral Subversion of the Nuclear Pore Complex
Lady Davis Institute at the Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
Department of Medicine, McGill University, Montreal, Quebec H3A 2B4, Canada
* Authors to whom correspondence should be addressed.
Received: 3 June 2013; in revised form: 29 July 2013 / Accepted: 8 August 2013 / Published: 16 August 2013
Abstract: The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
Keywords: viruses; nuclear pore complex; nucleoporins; nucleocytoplasmic transport
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Cite This Article
MDPI and ACS Style
Le Sage, V.; Mouland, A.J. Viral Subversion of the Nuclear Pore Complex. Viruses 2013, 5, 2019-2042.
Le Sage V, Mouland AJ. Viral Subversion of the Nuclear Pore Complex. Viruses. 2013; 5(8):2019-2042.
Le Sage, Valerie; Mouland, Andrew J. 2013. "Viral Subversion of the Nuclear Pore Complex." Viruses 5, no. 8: 2019-2042.