- freely available
Viral Subversion of the Nuclear Pore Complex
AbstractThe nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
Share & Cite This Article
Le Sage, V.; Mouland, A.J. Viral Subversion of the Nuclear Pore Complex. Viruses 2013, 5, 2019-2042.View more citation formats
Le Sage V, Mouland AJ. Viral Subversion of the Nuclear Pore Complex. Viruses. 2013; 5(8):2019-2042.Chicago/Turabian Style
Le Sage, Valerie; Mouland, Andrew J. 2013. "Viral Subversion of the Nuclear Pore Complex." Viruses 5, no. 8: 2019-2042.