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Viruses 2013, 5(8), 2019-2042; doi:10.3390/v5082019
Review

Viral Subversion of the Nuclear Pore Complex

1,2,*  and 1,2,*
Received: 3 June 2013 / Revised: 29 July 2013 / Accepted: 8 August 2013 / Published: 16 August 2013
(This article belongs to the Special Issue Viral Nuclear Import)
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Abstract

The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.
Keywords: viruses; nuclear pore complex; nucleoporins; nucleocytoplasmic transport viruses; nuclear pore complex; nucleoporins; nucleocytoplasmic transport
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Le Sage, V.; Mouland, A.J. Viral Subversion of the Nuclear Pore Complex. Viruses 2013, 5, 2019-2042.

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