Viruses 2013, 5(8), 2005-2018; doi:10.3390/v5082005
Article

A Polytropic Caprine Arthritis Encephalitis Virus Promoter Isolated from Multiple Tissues from a Sheep with Multisystemic Lentivirus-Associated Inflammatory Disease

1 Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA 2 California Animal Health and Food Safety Laboratory System, University of California, Davis, CA 95616, USA 3 Departamento Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain 4 Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
* Author to whom correspondence should be addressed.
Received: 5 July 2013; in revised form: 3 August 2013 / Accepted: 12 August 2013 / Published: 15 August 2013
(This article belongs to the Special Issue Small Ruminant Lentiviruses)
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Abstract: Caprine arthritis encephalitis virus (CAEV) is a lentivirus that infects both goats and sheep and is closely related to maedi-visna virus that infects sheep; collectively, these viruses are known as small ruminant lentiviruses (SRLV). Infection of goats and sheep with SRLV typically results in discrete inflammatory diseases which include arthritis, mastitis, pneumonia or encephalomyelitis. SRLV-infected animals concurrently demonstrating lentivirus-associated lesions in tissues of lung, mammary gland, joint synovium and the central nervous system are either very rare or have not been reported. Here we describe a novel CAEV promoter isolated from a sheep with multisystemic lentivirus-associated inflammatory disease including interstitial pneumonia, mastitis, polyarthritis and leukomyelitis. A single, novel SRLV promoter was cloned and sequenced from five different anatomical locations (brain stem, spinal cord, lung, mammary gland and carpal joint synovium), all of which demonstrated lesions characteristic of lentivirus associated inflammation. This SRLV promoter isolate was found to be closely related to CAEV promoters isolated from goats in northern California and other parts of the world. The promoter was denoted CAEV-ovine-MS (multisystemic disease); the stability of the transcription factor binding sites within the U3 promoter sequence are discussed.
Keywords: SRLV; CAEV; promoter; multisystemic

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MDPI and ACS Style

Adedeji, A.O.; Barr, B.; Gomez-Lucia, E.; Murphy, B. A Polytropic Caprine Arthritis Encephalitis Virus Promoter Isolated from Multiple Tissues from a Sheep with Multisystemic Lentivirus-Associated Inflammatory Disease. Viruses 2013, 5, 2005-2018.

AMA Style

Adedeji AO, Barr B, Gomez-Lucia E, Murphy B. A Polytropic Caprine Arthritis Encephalitis Virus Promoter Isolated from Multiple Tissues from a Sheep with Multisystemic Lentivirus-Associated Inflammatory Disease. Viruses. 2013; 5(8):2005-2018.

Chicago/Turabian Style

Adedeji, Adeyemi O.; Barr, Bradd; Gomez-Lucia, Esperanza; Murphy, Brian. 2013. "A Polytropic Caprine Arthritis Encephalitis Virus Promoter Isolated from Multiple Tissues from a Sheep with Multisystemic Lentivirus-Associated Inflammatory Disease." Viruses 5, no. 8: 2005-2018.

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