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Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction
Genomics and Health Group, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country UPV/EHU, Bilbao 48080, Spain
* Author to whom correspondence should be addressed.
Received: 3 June 2013; in revised form: 26 July 2013 / Accepted: 5 August 2013 / Published: 19 August 2013
Abstract: Small ruminant lentiviruses (SRLV) are members of the Retrovirus family comprising the closely related Visna/Maedi Virus (VMV) and the Caprine Arthritis-Encephalitis Virus (CAEV), which infect sheep and goats. Both infect cells of the monocyte/macrophage lineage and cause lifelong infections. Infection by VMV and CAEV can lead to Visna/Maedi (VM) and Caprine Arthritis-Encephalitis (CAE) respectively, slow progressive inflammatory diseases primarily affecting the lungs, nervous system, joints and mammary glands. VM and CAE are distributed worldwide and develop over a period of months or years, always leading to the death of the host, with the consequent economic and welfare implications. Currently, the control of VM and CAE relies on the control of transmission and culling of infected animals. However, there is evidence that host genetics play an important role in determining Susceptibility/Resistance to SRLV infection and disease progression, but little work has been performed in small ruminants. More research is necessary to understand the host-SRLV interaction.
Keywords: small ruminants; lentivirus; Visna/Maedi; caprine arthritis encephalitis; host genetics
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MDPI and ACS Style
Larruskain, A.; Jugo, B.M. Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction. Viruses 2013, 5, 2043-2061.
Larruskain A, Jugo BM. Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction. Viruses. 2013; 5(8):2043-2061.
Larruskain, Amaia; Jugo, Begoña M. 2013. "Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction." Viruses 5, no. 8: 2043-2061.