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Immunization against Small Ruminant Lentiviruses
Institute of Agrobiotechnology, CSIC-UPNA-Government of Navarra, Ctra. Mutilva Baja s/n, Navarra 31192, Spain
* Author to whom correspondence should be addressed.
Received: 14 June 2013; in revised form: 24 July 2013 / Accepted: 25 July 2013 / Published: 2 August 2013
Abstract: Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered interest in exploring different strategies of immunization to control the widely spread SRLV infection and, also, to provide a useful model for HIV vaccines. These strategies involve inactivated whole virus, subunit vaccines, DNA encoding viral proteins in the presence or absence of plasmids encoding immunological adjuvants and naturally or artificially attenuated viruses. In this review, we revisit, comprehensively, the immunization strategies against SRLV and analyze this double edged tool individually, as it may contribute to either controlling or enhancing virus replication and/or disease.
Keywords: small ruminant lentivirus; Maedi-Visna; immunization
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MDPI and ACS Style
Reina, R.; Andrés, D.D.; Amorena, B. Immunization against Small Ruminant Lentiviruses. Viruses 2013, 5, 1948-1963.
Reina R, Andrés DD, Amorena B. Immunization against Small Ruminant Lentiviruses. Viruses. 2013; 5(8):1948-1963.
Reina, Ramsés; Andrés, Damián D.; Amorena, Beatriz. 2013. "Immunization against Small Ruminant Lentiviruses." Viruses 5, no. 8: 1948-1963.