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Viruses 2012, 4(9), 1410-1424; doi:10.3390/v4091410

Structural Aspects of the Interaction of Dairy Phages with Their Host Bacteria

1 Department of Microbiology, University College Cork, Western Road, Cork, Ireland 2 Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Western Road, Cork, Ireland
* Author to whom correspondence should be addressed.
Received: 13 July 2012 / Revised: 22 August 2012 / Accepted: 23 August 2012 / Published: 31 August 2012
(This article belongs to the Special Issue Recent Progress in Bacteriophage Research)
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Knowledge of phage-host interactions at a fundamental level is central to the design of rational strategies for the development of phage-resistant strains that may be applied in industrial settings. Phages infecting lactic acid bacteria, in particular Lactococcus lactis and Streptococcus thermophilus, negatively impact on dairy fermentation processes with serious economic implications. In recent years a wealth of information on structural protein assembly and topology has become available relating to phages infecting Escherichia coli, Bacillus subtilis and Lactococcus lactis, which act as models for structural analyses of dairy phages. In this review, we explore the role of model tailed phages, such as T4 and SPP1, in advancing our knowledge regarding interactions between dairy phages and their hosts. Furthermore, the potential of currently investigated dairy phages to in turn serve as model systems for this particular group of phages is discussed.
Keywords: bacteriophage; milk fermentation; receptor bacteriophage; milk fermentation; receptor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mahony, J.; van Sinderen, D. Structural Aspects of the Interaction of Dairy Phages with Their Host Bacteria. Viruses 2012, 4, 1410-1424.

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