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Picornavirus Subversion of the Autophagy Pathway
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
* Author to whom correspondence should be addressed.
Received: 9 June 2011; in revised form: 9 August 2011 / Accepted: 15 August 2011 / Published: 26 August 2011
Abstract: While autophagy has been shown to act as an anti-viral defense, the Picornaviridae avoid and, in many cases, subvert this pathway to promote their own replication. Evidence indicates that some picornaviruses hijack autophagy in order to induce autophagosome-like membrane structures for genomic RNA replication. Expression of picornavirus proteins can specifically induce the machinery of autophagy, although the mechanisms by which the viruses employ autophagy appear to differ. Many picornaviruses up-regulate autophagy in order to promote viral replication while some members of the family also inhibit degradation by autolysosomes. Here we explore the unusual relationship of this medically important family of viruses with a degradative mechanism of innate immunity.
Keywords: picornavirus; autophagy; membranes; viral replication
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Klein, K.A.; Jackson, W.T. Picornavirus Subversion of the Autophagy Pathway. Viruses 2011, 3, 1549-1561.
Klein KA, Jackson WT. Picornavirus Subversion of the Autophagy Pathway. Viruses. 2011; 3(9):1549-1561.
Klein, Kathryn A.; Jackson, William T. 2011. "Picornavirus Subversion of the Autophagy Pathway." Viruses 3, no. 9: 1549-1561.