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Impact of the Autophagy Machinery on Hepatitis C Virus Infection
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
Ecole Normale Supérieure de Lyon, Lyon, F-69007, France
Université de Lyon, Lyon, F-69007, France
INSERM, U758, Lyon, F-69007, France
* Authors to whom correspondence should be addressed.
Received: 16 June 2011; in revised form: 20 July 2011 / Accepted: 21 July 2011 / Published: 4 August 2011
Abstract: Autophagy is a cellular process that catabolizes cytoplasmic components and maintains energy homeostasis. As a stress response, the autophagy machinery interconnects a wide range of cellular pathways, enhancing the spread of certain pathogens while limiting others, and has become a highly active research area over the past several years. Independent laboratories have recently reported that autophagy vesicles accumulate in hepatitis C virus (HCV) infected cells and that autophagy proteins can function as proviral factors required for HCV replication. In this review, we summarize what is currently known about the interplay between autophagy and HCV and the possible mechanisms whereby autophagy proteins might favor HCV propagation.
Keywords: hepatitis C virus; HCV; autophagy; autophagic vesicle; autolysosome; unfolded protein response; ER-stress response; innate host response; interferon; RIG-I
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Cite This Article
MDPI and ACS Style
Dreux, M.; Chisari, F.V. Impact of the Autophagy Machinery on Hepatitis C Virus Infection. Viruses 2011, 3, 1342-1357.
Dreux M, Chisari FV. Impact of the Autophagy Machinery on Hepatitis C Virus Infection. Viruses. 2011; 3(8):1342-1357.
Dreux, Marlène; Chisari, Francis V. 2011. "Impact of the Autophagy Machinery on Hepatitis C Virus Infection." Viruses 3, no. 8: 1342-1357.