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Viruses 2011, 3(8), 1342-1357; doi:10.3390/v3081342

Impact of the Autophagy Machinery on Hepatitis C Virus Infection

1
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
2
Ecole Normale Supérieure de Lyon, Lyon, F-69007, France
3
Université de Lyon, Lyon, F-69007, France
4
INSERM, U758, Lyon, F-69007, France
*
Authors to whom correspondence should be addressed.
Received: 16 June 2011 / Revised: 20 July 2011 / Accepted: 21 July 2011 / Published: 4 August 2011
(This article belongs to the Special Issue Autophagy and Viruses)
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Abstract

Autophagy is a cellular process that catabolizes cytoplasmic components and maintains energy homeostasis. As a stress response, the autophagy machinery interconnects a wide range of cellular pathways, enhancing the spread of certain pathogens while limiting others, and has become a highly active research area over the past several years. Independent laboratories have recently reported that autophagy vesicles accumulate in hepatitis C virus (HCV) infected cells and that autophagy proteins can function as proviral factors required for HCV replication. In this review, we summarize what is currently known about the interplay between autophagy and HCV and the possible mechanisms whereby autophagy proteins might favor HCV propagation.
Keywords: hepatitis C virus; HCV; autophagy; autophagic vesicle; autolysosome; unfolded protein response; ER-stress response; innate host response; interferon; RIG-I hepatitis C virus; HCV; autophagy; autophagic vesicle; autolysosome; unfolded protein response; ER-stress response; innate host response; interferon; RIG-I
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dreux, M.; Chisari, F.V. Impact of the Autophagy Machinery on Hepatitis C Virus Infection. Viruses 2011, 3, 1342-1357.

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