Viruses 2011, 3(9), 1562-1608; doi:10.3390/v3091562
Dengue — Quo tu et quo vadis?
1
Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
2
Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
3
Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
4
Center for Tropical Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
*
Author to whom correspondence should be addressed.
Received: 8 July 2011 / Revised: 12 August 2011 / Accepted: 12 August 2011 / Published: 1 September 2011
(This article belongs to the Special Issue Recent Progress in Dengue Virus Research)
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Abstract
Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence.Keywords:
dengue virus (DENV); arbovirus; mosquito; evolution; phylogenetics
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MDPI and ACS Style
Chen, R.; Vasilakis, N. Dengue — Quo tu et quo vadis? Viruses 2011, 3, 1562-1608.