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Viruses 2011, 3(9), 1562-1608; doi:10.3390/v3091562

Dengue — Quo tu et quo vadis?

Received: 8 July 2011 / Revised: 12 August 2011 / Accepted: 12 August 2011 / Published: 1 September 2011
(This article belongs to the Special Issue Recent Progress in Dengue Virus Research)
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Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence.
Keywords: dengue virus (DENV); arbovirus; mosquito; evolution; phylogenetics dengue virus (DENV); arbovirus; mosquito; evolution; phylogenetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, R.; Vasilakis, N. Dengue — Quo tu et quo vadis? Viruses 2011, 3, 1562-1608.

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