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Viruses 2011, 3(8), 1501-1531; doi:10.3390/v3081501
Review

Intracellular Events and Cell Fate in Filovirus Infection

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Received: 7 June 2011; in revised form: 9 August 2011 / Accepted: 15 August 2011 / Published: 24 August 2011
(This article belongs to the Special Issue Pathogenesis of Emerging and Re-Emerging RNA Viruses)
Download PDF [4936 KB, uploaded 24 August 2011]
Abstract: Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood and lymph flow. A hallmark of filovirus infection is the depletion of non-infected lymphocytes; however, the molecular mechanisms leading to the observed bystander lymphocyte apoptosis are poorly understood. Also, there is limited knowledge about the fate of infected cells in filovirus disease. In this review we will explore what is known about the intracellular events leading to virus amplification and cell damage in filovirus infection. Furthermore, we will discuss how cellular dysfunction and cell death may correlate with disease pathogenesis.
Keywords: Ebola Virus; Marburg Virus; filoviruses; viral replication cycle; target cells; animal models; ultrastructural analysis; virus-cell interaction; bystander apoptosis; cell death Ebola Virus; Marburg Virus; filoviruses; viral replication cycle; target cells; animal models; ultrastructural analysis; virus-cell interaction; bystander apoptosis; cell death
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Olejnik, J.; Ryabchikova, E.; Corley, R.B.; Mühlberger, E. Intracellular Events and Cell Fate in Filovirus Infection. Viruses 2011, 3, 1501-1531.

AMA Style

Olejnik J, Ryabchikova E, Corley RB, Mühlberger E. Intracellular Events and Cell Fate in Filovirus Infection. Viruses. 2011; 3(8):1501-1531.

Chicago/Turabian Style

Olejnik, Judith; Ryabchikova, Elena; Corley, Ronald B.; Mühlberger, Elke. 2011. "Intracellular Events and Cell Fate in Filovirus Infection." Viruses 3, no. 8: 1501-1531.


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