Next Article in Journal
Human T-Lymphotropic Virus Type 1 (HTLV-1) and Regulatory T Cells in HTLV-1-Associated Neuroinflammatory Disease
Next Article in Special Issue
Filoviral Immune Evasion Mechanisms
Previous Article in Journal
Direct Inhibition of RNAse T2 Expression by the HTLV-1 Viral Protein Tax
Previous Article in Special Issue
T Cells and Pathogenesis of Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome
Viruses 2011, 3(8), 1501-1531; doi:10.3390/v3081501
Review

Intracellular Events and Cell Fate in Filovirus Infection

1,2
,
3
,
1,2
 and
1,2,*
Received: 7 June 2011 / Revised: 9 August 2011 / Accepted: 15 August 2011 / Published: 24 August 2011
(This article belongs to the Special Issue Pathogenesis of Emerging and Re-Emerging RNA Viruses)
Download PDF [4936 KB, uploaded 12 May 2015]

Abstract

Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood and lymph flow. A hallmark of filovirus infection is the depletion of non-infected lymphocytes; however, the molecular mechanisms leading to the observed bystander lymphocyte apoptosis are poorly understood. Also, there is limited knowledge about the fate of infected cells in filovirus disease. In this review we will explore what is known about the intracellular events leading to virus amplification and cell damage in filovirus infection. Furthermore, we will discuss how cellular dysfunction and cell death may correlate with disease pathogenesis.
Keywords: Ebola Virus; Marburg Virus; filoviruses; viral replication cycle; target cells; animal models; ultrastructural analysis; virus-cell interaction; bystander apoptosis; cell death Ebola Virus; Marburg Virus; filoviruses; viral replication cycle; target cells; animal models; ultrastructural analysis; virus-cell interaction; bystander apoptosis; cell death
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Olejnik, J.; Ryabchikova, E.; Corley, R.B.; Mühlberger, E. Intracellular Events and Cell Fate in Filovirus Infection. Viruses 2011, 3, 1501-1531.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert