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Dengue Virus and Autophagy
Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA
* Author to whom correspondence should be addressed.
Received: 17 June 2011; in revised form: 19 July 2011 / Accepted: 21 July 2011 / Published: 4 August 2011
Abstract: Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV). Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM tomography of DENV replication complexes showed that DENV replicates on endoplasmic reticulum (ER) cisternae invaginations and not on classical autophagosomes. Recently, it was reported that autophagy plays an indirect role in DENV replication by modulating cellular lipid metabolism. DENV-induced autophagosomes deplete cellular triglycerides that are stored in lipid droplets, leading to increased β-oxidation and energy production. This is the first example of a virus triggering autophagy to modulate cellular physiology. In this review, we summarize these data and discuss new questions and implications for autophagy during DENV replication.
Keywords: lipid metabolism; lipophagy; lipid droplet; b-oxidation
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MDPI and ACS Style
Heaton, N.S.; Randall, G. Dengue Virus and Autophagy. Viruses 2011, 3, 1332-1341.
Heaton NS, Randall G. Dengue Virus and Autophagy. Viruses. 2011; 3(8):1332-1341.
Heaton, Nicholas S.; Randall, Glenn. 2011. "Dengue Virus and Autophagy." Viruses 3, no. 8: 1332-1341.