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Viruses, Autophagy Genes, and Crohn’s Disease
AbstractThe etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.
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Hubbard, V.M.; Cadwell, K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses 2011, 3, 1281-1311.View more citation formats
Hubbard VM, Cadwell K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses. 2011; 3(7):1281-1311.Chicago/Turabian Style
Hubbard, Vanessa M.; Cadwell, Ken. 2011. "Viruses, Autophagy Genes, and Crohn’s Disease." Viruses 3, no. 7: 1281-1311.
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