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Viruses, Autophagy Genes, and Crohn’s Disease
Skirball Institute of Biomolecular Medicine, Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
* Author to whom correspondence should be addressed.
Received: 8 June 2011; in revised form: 12 July 2011 / Accepted: 13 July 2011 / Published: 21 July 2011
Abstract: The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.
Keywords: Crohn’s disease; inflammatory bowel disease; norovirus; MNV; ATG16L1; autophagy; mucosal immunity; intestine; Paneth cells
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Cite This Article
MDPI and ACS Style
Hubbard, V.M.; Cadwell, K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses 2011, 3, 1281-1311.
Hubbard VM, Cadwell K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses. 2011; 3(7):1281-1311.
Hubbard, Vanessa M.; Cadwell, Ken. 2011. "Viruses, Autophagy Genes, and Crohn’s Disease." Viruses 3, no. 7: 1281-1311.