Viruses 2011, 3(7), 1281-1311; doi:10.3390/v3071281
Review

Viruses, Autophagy Genes, and Crohn’s Disease

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Received: 8 June 2011; in revised form: 12 July 2011 / Accepted: 13 July 2011 / Published: 21 July 2011
(This article belongs to the Special Issue Autophagy and Viruses)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The etiology of the intestinal disease Crohn’s disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn’s disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.
Keywords: Crohn’s disease; inflammatory bowel disease; norovirus; MNV; ATG16L1; autophagy; mucosal immunity; intestine; Paneth cells
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MDPI and ACS Style

Hubbard, V.M.; Cadwell, K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses 2011, 3, 1281-1311.

AMA Style

Hubbard VM, Cadwell K. Viruses, Autophagy Genes, and Crohn’s Disease. Viruses. 2011; 3(7):1281-1311.

Chicago/Turabian Style

Hubbard, Vanessa M.; Cadwell, Ken. 2011. "Viruses, Autophagy Genes, and Crohn’s Disease." Viruses 3, no. 7: 1281-1311.


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