Next Article in Journal
Ectromelia Virus Infections of Mice as a Model to Support the Licensure of Anti-Orthopoxvirus Therapeutics
Next Article in Special Issue
Improving Adenovirus Based Gene Transfer: Strategies to Accomplish Immune Evasion
Previous Article in Journal
JaPaFi: A Novel Program for the Identification of Highly Conserved DNA Sequences
Previous Article in Special Issue
Increasing the Efficacy of Oncolytic Adenovirus Vectors
Viruses 2010, 2(9), 1886-1917; doi:10.3390/v2091886
Review

Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives

 and *
Received: 21 June 2010; in revised form: 26 August 2010 / Accepted: 30 August 2010 / Published: 3 September 2010
(This article belongs to the Special Issue Adenoviral Vectors)
Download PDF [1586 KB, uploaded 3 September 2010]
Abstract: Recombinant Adenoviral vectors represent one of the best gene transfer platforms due to their ability to efficiently transduce a wide range of quiescent and proliferating cell types from various tissues and species. The activation of an adaptive immune response against the transduced cells is one of the major drawbacks of first generation Adenovirus vectors and has been overcome by the latest generation of recombinant Adenovirus, the Helper-Dependent Adenoviral (HDAd) vectors. HDAds have innovative features including the complete absence of viral coding sequences and the ability to mediate high level transgene expression with negligible chronic toxicity. This review summarizes the many aspects of HDAd biology and structure with a major focus on in vivo gene therapy application and with an emphasis on the unsolved issues that these vectors still presents toward clinical application.
Keywords: Helper Dependent Adenovirus; liver transduction; lung transduction; innate and adaptive immune response Helper Dependent Adenovirus; liver transduction; lung transduction; innate and adaptive immune response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Vetrini, F.; Ng, P. Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives. Viruses 2010, 2, 1886-1917.

AMA Style

Vetrini F, Ng P. Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives. Viruses. 2010; 2(9):1886-1917.

Chicago/Turabian Style

Vetrini, Francesco; Ng, Philip. 2010. "Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives." Viruses 2, no. 9: 1886-1917.


Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert