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Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston , TX, USA
* Author to whom correspondence should be addressed.
Received: 21 June 2010; in revised form: 26 August 2010 / Accepted: 30 August 2010 / Published: 3 September 2010
Abstract: Recombinant Adenoviral vectors represent one of the best gene transfer platforms due to their ability to efficiently transduce a wide range of quiescent and proliferating cell types from various tissues and species. The activation of an adaptive immune response against the transduced cells is one of the major drawbacks of first generation Adenovirus vectors and has been overcome by the latest generation of recombinant Adenovirus, the Helper-Dependent Adenoviral (HDAd) vectors. HDAds have innovative features including the complete absence of viral coding sequences and the ability to mediate high level transgene expression with negligible chronic toxicity. This review summarizes the many aspects of HDAd biology and structure with a major focus on in vivo gene therapy application and with an emphasis on the unsolved issues that these vectors still presents toward clinical application.
Keywords: Helper Dependent Adenovirus; liver transduction; lung transduction; innate and adaptive immune response
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MDPI and ACS Style
Vetrini, F.; Ng, P. Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives. Viruses 2010, 2, 1886-1917.
Vetrini F, Ng P. Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives. Viruses. 2010; 2(9):1886-1917.
Vetrini, Francesco; Ng, Philip. 2010. "Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives." Viruses 2, no. 9: 1886-1917.