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Viruses 2010, 2(8), 1603-1620; doi:10.3390/v2081603
Review

Macrophages and Cell-Cell Spread of HIV-1

 and
*
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
* Author to whom correspondence should be addressed.
Received: 14 June 2010 / Revised: 22 July 2010 / Accepted: 27 July 2010 / Published: 5 August 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Abstract

Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.
Keywords: HIV-1; macrophage; synapse; transmission HIV-1; macrophage; synapse; transmission
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Waki, K.; Freed, E.O. Macrophages and Cell-Cell Spread of HIV-1. Viruses 2010, 2, 1603-1620.

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