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Viruses 2010, 2(8), 1603-1620; doi:10.3390/v2081603
Review

Macrophages and Cell-Cell Spread of HIV-1

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Received: 14 June 2010 / Revised: 22 July 2010 / Accepted: 27 July 2010 / Published: 5 August 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Abstract

Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.
Keywords: HIV-1; macrophage; synapse; transmission HIV-1; macrophage; synapse; transmission
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Waki, K.; Freed, E.O. Macrophages and Cell-Cell Spread of HIV-1. Viruses 2010, 2, 1603-1620.

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