- freely available
Macrophages and Cell-Cell Spread of HIV-1
AbstractMacrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.
Share & Cite This Article
Waki, K.; Freed, E.O. Macrophages and Cell-Cell Spread of HIV-1. Viruses 2010, 2, 1603-1620.View more citation formats
Waki K, Freed EO. Macrophages and Cell-Cell Spread of HIV-1. Viruses. 2010; 2(8):1603-1620.Chicago/Turabian Style
Waki, Kayoko; Freed, Eric O. 2010. "Macrophages and Cell-Cell Spread of HIV-1." Viruses 2, no. 8: 1603-1620.
Notes: Multiple requests from the same IP address are counted as one view.