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Viruses 2010, 2(8), 1666-1680; doi:10.3390/v2081666

HIV-1 Virological Synapse: Live Imaging of Transmission

*  and *
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France
* Authors to whom correspondence should be addressed.
Received: 15 July 2010 / Revised: 5 August 2010 / Accepted: 11 August 2010 / Published: 12 August 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.
Keywords: HIV-1; virological synapse; live video-microscopy HIV-1; virological synapse; live video-microscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Feldmann, J.; Schwartz, O. HIV-1 Virological Synapse: Live Imaging of Transmission. Viruses 2010, 2, 1666-1680.

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