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HIV-1 Virological Synapse: Live Imaging of Transmission
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France
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Received: 15 July 2010; in revised form: 5 August 2010 / Accepted: 11 August 2010 / Published: 12 August 2010
Abstract: A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.
Keywords: HIV-1; virological synapse; live video-microscopy
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Feldmann, J.; Schwartz, O. HIV-1 Virological Synapse: Live Imaging of Transmission. Viruses 2010, 2, 1666-1680.
Feldmann J, Schwartz O. HIV-1 Virological Synapse: Live Imaging of Transmission. Viruses. 2010; 2(8):1666-1680.
Feldmann, Jerome; Schwartz, Olivier. 2010. "HIV-1 Virological Synapse: Live Imaging of Transmission." Viruses 2, no. 8: 1666-1680.