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Viruses 2010, 2(8), 1666-1680; doi:10.3390/v2081666
Review

HIV-1 Virological Synapse: Live Imaging of Transmission

*  and *
Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France
* Authors to whom correspondence should be addressed.
Received: 15 July 2010 / Revised: 5 August 2010 / Accepted: 11 August 2010 / Published: 12 August 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Abstract

A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.
Keywords: HIV-1; virological synapse; live video-microscopy HIV-1; virological synapse; live video-microscopy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Feldmann, J.; Schwartz, O. HIV-1 Virological Synapse: Live Imaging of Transmission. Viruses 2010, 2, 1666-1680.

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