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Viruses 2010, 2(6), 1306-1321; doi:10.3390/v2061306

Cell-to-Cell Spread of Retroviruses

The Sir William Dunn School of Pathology, The University of Oxford, South Parks Road, Oxford OX13RE, UK
Received: 19 April 2010 / Revised: 2 June 2010 / Accepted: 3 June 2010 / Published: 10 June 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Viruses from several families use direct cell-to-cell infection to disseminate between cells. Retroviruses are a relatively recent addition to this list, and appear to spread cell-to-cell by induction of multimolecular complexes termed virological synapses that assemble at the interface between infected and receptor-expressing target cells. Over the past five years, detailed insight into the cellular and molecular basis of virological synapse-mediated retroviral cell-to-cell spread has been obtained, but important questions and controversies have been raised that remain to be resolved. This review will focus on recent advances in the field with emphasis on areas in which work still needs to be done.
Keywords: HIV-1; virological synapse; CD4+ T cell; macrophage; dendritic cell; membrane fusion; endocytosis; immune evasion HIV-1; virological synapse; CD4+ T cell; macrophage; dendritic cell; membrane fusion; endocytosis; immune evasion
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sattentau, Q.J. Cell-to-Cell Spread of Retroviruses. Viruses 2010, 2, 1306-1321.

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