Next Article in Journal
Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
Next Article in Special Issue
The HTLV-1 Virological Synapse
Previous Article in Journal
Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections
Previous Article in Special Issue
T Cell Polarization at the Virological Synapse
Article Menu

Export Article

Open AccessReview
Viruses 2010, 2(6), 1306-1321; doi:10.3390/v2061306

Cell-to-Cell Spread of Retroviruses

The Sir William Dunn School of Pathology, The University of Oxford, South Parks Road, Oxford OX13RE, UK
Received: 19 April 2010 / Revised: 2 June 2010 / Accepted: 3 June 2010 / Published: 10 June 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
View Full-Text   |   Download PDF [221 KB, uploaded 12 May 2015]   |  

Abstract

Viruses from several families use direct cell-to-cell infection to disseminate between cells. Retroviruses are a relatively recent addition to this list, and appear to spread cell-to-cell by induction of multimolecular complexes termed virological synapses that assemble at the interface between infected and receptor-expressing target cells. Over the past five years, detailed insight into the cellular and molecular basis of virological synapse-mediated retroviral cell-to-cell spread has been obtained, but important questions and controversies have been raised that remain to be resolved. This review will focus on recent advances in the field with emphasis on areas in which work still needs to be done.
Keywords: HIV-1; virological synapse; CD4+ T cell; macrophage; dendritic cell; membrane fusion; endocytosis; immune evasion HIV-1; virological synapse; CD4+ T cell; macrophage; dendritic cell; membrane fusion; endocytosis; immune evasion
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sattentau, Q.J. Cell-to-Cell Spread of Retroviruses. Viruses 2010, 2, 1306-1321.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top