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HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse
Viruses 2010, 2(6), 1261-1278; doi:10.3390/v2061261
Review

T Cell Polarization at the Virological Synapse

Received: 25 March 2010; in revised form: 20 May 2010 / Accepted: 28 May 2010 / Published: 31 May 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Abstract: Cell-to-cell spread of HIV-1 between CD4+ T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
Keywords: HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jolly, C. T Cell Polarization at the Virological Synapse. Viruses 2010, 2, 1261-1278.

AMA Style

Jolly C. T Cell Polarization at the Virological Synapse. Viruses. 2010; 2(6):1261-1278.

Chicago/Turabian Style

Jolly, Clare. 2010. "T Cell Polarization at the Virological Synapse." Viruses 2, no. 6: 1261-1278.


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