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T Cell Polarization at the Virological Synapse
MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, W1T 4JF, UK
Received: 25 March 2010; in revised form: 20 May 2010 / Accepted: 28 May 2010 / Published: 31 May 2010
Abstract: Cell-to-cell spread of HIV-1 between CD4+ T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
Keywords: HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion
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Cite This Article
MDPI and ACS Style
Jolly, C. T Cell Polarization at the Virological Synapse. Viruses 2010, 2, 1261-1278.
Jolly C. T Cell Polarization at the Virological Synapse. Viruses. 2010; 2(6):1261-1278.
Jolly, Clare. 2010. "T Cell Polarization at the Virological Synapse." Viruses 2, no. 6: 1261-1278.