Viruses 2010, 2(6), 1261-1278; doi:10.3390/v2061261

T Cell Polarization at the Virological Synapse

MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, W1T 4JF, UK
Received: 25 March 2010; in revised form: 20 May 2010 / Accepted: 28 May 2010 / Published: 31 May 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
PDF Full-text Download PDF Full-Text [167 KB, uploaded 31 May 2010 10:36 CEST]
Abstract: Cell-to-cell spread of HIV-1 between CD4+ T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
Keywords: HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Jolly, C. T Cell Polarization at the Virological Synapse. Viruses 2010, 2, 1261-1278.

AMA Style

Jolly C. T Cell Polarization at the Virological Synapse. Viruses. 2010; 2(6):1261-1278.

Chicago/Turabian Style

Jolly, Clare. 2010. "T Cell Polarization at the Virological Synapse." Viruses 2, no. 6: 1261-1278.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert