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Viruses 2010, 2(6), 1261-1278; doi:10.3390/v2061261

T Cell Polarization at the Virological Synapse

MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, W1T 4JF, UK
Received: 25 March 2010 / Revised: 20 May 2010 / Accepted: 28 May 2010 / Published: 31 May 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Abstract

Cell-to-cell spread of HIV-1 between CD4+ T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
Keywords: HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion HIV; T cell; virological synapse; polarization; cytoskeleton; MTOC; secretion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Jolly, C. T Cell Polarization at the Virological Synapse. Viruses 2010, 2, 1261-1278.

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