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Viruses 2010, 2(6), 1279-1305; doi:10.3390/v2061279

Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections

Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
This paper is to be considered as a revised and updated version of the paper published by Férir et al.: Ferir, G.; Kaptein, S.; Neyts, J., De Clercq, E. Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future. Rev. Med. Virol. 2008, 18, 19-34.
Author to whom correspondence should be addressed.
Received: 9 March 2010 / Revised: 18 May 2010 / Accepted: 25 May 2010 / Published: 31 May 2010
(This article belongs to the Special Issue Hepatitis Viruses)
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While 25 compounds have been formally licensed for the treatment of HIV infection (AIDS), only seven licensed products are currently available for the treatment of chronic hepatitis B virus (HBV) infection: interferon-α, pegylated interferon-α, lamivudine, adefovir (dipivoxil), entecavir, telbivudine and tenofovir (disoproxil fumarate). In contrast to the treatment of HIV infections where the individual drugs are routinely used in combination, for the treatment of chronic HBV infection the individual drugs are generally used in monotherapy. In principle, combination drug therapy should allow reducing the likelihood of drug-resistant development.
Keywords: antiviral therapy; HBV therapy; nucleoside analogs; viral hepatitis antiviral therapy; HBV therapy; nucleoside analogs; viral hepatitis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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De Clercq, E.; Férir, G.; Kaptein, S.; Neyts, J. Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections. Viruses 2010, 2, 1279-1305.

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