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HIV Nuclear Entry: Clearing the Fog
AbstractHIV-1 and other lentiviruses have the unusual capability of infecting nondividing cells, but the mechanism by which they cross an intact nuclear membrane is mysterious. Recent work, including a new study (Lee, K.; Ambrose, Z.; Martin, T.D.; Oztop, I.; Mulky, A.; Julias, J.G.; Vandergraaff, N.; Baumann, J.G.; Wang, R.; Yuen, W. et al. Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe 2010,7, 221-233) confirms that the viral capsid plays a key role in HIV-1 nuclear entry in both dividing and nondividing cells. The identification of mutations in the viral capsid that alter the virus’s dependence on host cell nucleoporins represents an important advance in this poorly understood stage of the virus life cycle.
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Shah, V.B.; Aiken, C. HIV Nuclear Entry: Clearing the Fog. Viruses 2010, 2, 1190-1194.View more citation formats
Shah VB, Aiken C. HIV Nuclear Entry: Clearing the Fog. Viruses. 2010; 2(5):1190-1194.Chicago/Turabian Style
Shah, Vaibhav B.; Aiken, Christopher. 2010. "HIV Nuclear Entry: Clearing the Fog." Viruses 2, no. 5: 1190-1194.