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Viruses 2010, 2(5), 1055-1068; doi:10.3390/v2051055

Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function

1
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA
2
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
3
Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Received: 31 January 2010 / Revised: 7 April 2010 / Accepted: 22 April 2010 / Published: 29 April 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
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Abstract

Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process. View Full-Text
Keywords: RNA viruses; replication; membranes; lipids RNA viruses; replication; membranes; lipids
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Stapleford, K.A.; Miller, D.J. Role of Cellular Lipids in Positive-Sense RNA Virus Replication Complex Assembly and Function. Viruses 2010, 2, 1055-1068.

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