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HIV-1 Entry, Inhibitors, and Resistance
AbstractEntry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical use. Several potential mechanisms have been proposed: tropism switching (utilization of CXCR4 instead of CCR5 for entry), increased affinity for the coreceptor, increased rate of virus entry into host cells, and utilization of inhibitor-bound receptor for entry. In this review we will address the development of attachment, fusion, and coreceptor entry inhibitors and explore recent studies describing potential mechanisms of resistance.
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Lobritz, M.A.; Ratcliff, A.N.; Arts, E.J. HIV-1 Entry, Inhibitors, and Resistance. Viruses 2010, 2, 1069-1105.View more citation formats
Lobritz MA, Ratcliff AN, Arts EJ. HIV-1 Entry, Inhibitors, and Resistance. Viruses. 2010; 2(5):1069-1105.Chicago/Turabian Style
Lobritz, Michael A.; Ratcliff, Annette N.; Arts, Eric J. 2010. "HIV-1 Entry, Inhibitors, and Resistance." Viruses 2, no. 5: 1069-1105.