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Viruses 2010, 2(5), 1069-1105; doi:10.3390/v2051069
Review

HIV-1 Entry, Inhibitors, and Resistance

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Received: 23 February 2010; in revised form: 16 April 2010 / Accepted: 18 April 2010 / Published: 29 April 2010
(This article belongs to the Special Issue HIV Drug Resistance 2010)
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Abstract: Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical use. Several potential mechanisms have been proposed: tropism switching (utilization of CXCR4 instead of CCR5 for entry), increased affinity for the coreceptor, increased rate of virus entry into host cells, and utilization of inhibitor-bound receptor for entry. In this review we will address the development of attachment, fusion, and coreceptor entry inhibitors and explore recent studies describing potential mechanisms of resistance.
Keywords: HIV-1; envelope; gp120; V3 loop; gp41; CCR5; maraviroc; vicriviroc HIV-1; envelope; gp120; V3 loop; gp41; CCR5; maraviroc; vicriviroc
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lobritz, M.A.; Ratcliff, A.N.; Arts, E.J. HIV-1 Entry, Inhibitors, and Resistance. Viruses 2010, 2, 1069-1105.

AMA Style

Lobritz MA, Ratcliff AN, Arts EJ. HIV-1 Entry, Inhibitors, and Resistance. Viruses. 2010; 2(5):1069-1105.

Chicago/Turabian Style

Lobritz, Michael A.; Ratcliff, Annette N.; Arts, Eric J. 2010. "HIV-1 Entry, Inhibitors, and Resistance." Viruses 2, no. 5: 1069-1105.


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