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Viruses 2009, 1(3), 965-978; doi:10.3390/v1030965

Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act

Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, USA
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
Author to whom correspondence should be addressed.
Received: 30 September 2009 / Revised: 16 November 2009 / Accepted: 17 November 2009 / Published: 18 November 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
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Apoptosis is triggered as an intrinsic defense against numerous viral infections. Almost every virus encodes apoptotic modulators, and the herpes simplex viruses (HSV) are no exception. During HSV infection, there is an intricate balance between pro- and anti-apoptotic factors that delays apoptotic death until the virus has replicated. Perturbations in the apoptotic balance can cause premature cell death and have the potential to dramatically alter the outcome of infection. Recently, certain cellular genes have been shown to regulate sensitivity to HSV-dependent apoptosis. This review summarizes current knowledge of the cellular genes that impact the apoptotic balance during HSV infection.
Keywords: Herpes Simplex Virus; apoptosis; virus-host interactions Herpes Simplex Virus; apoptosis; virus-host interactions

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nguyen, M.L.; Blaho, J.A. Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act. Viruses 2009, 1, 965-978.

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