Next Article in Journal
The Complete Sequence of a Human Parainfluenzavirus 4 Genome
Next Article in Special Issue
Herpes Virus Amplicon Vectors
Previous Article in Journal
Human Bocavirus – Insights into a Newly Identified Respiratory Virus
Article Menu

Export Article

Open AccessReview
Viruses 2009, 1(1), 13-25; doi:10.3390/v1010013

Alphaviruses in Gene Therapy

PanTherapeutics, Rue des Remparts 4, CH1095 Lutry, Switzerland
Received: 2 April 2009 / Revised: 15 April 2009 / Accepted: 20 April 2009 / Published: 21 April 2009
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
View Full-Text   |   Download PDF [653 KB, uploaded 12 May 2015]   |  


Alphaviruses are enveloped single stranded RNA viruses, which as gene therapy vectors provide high-level transient gene expression. Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan Equine Encephalitis (VEE) virus have been engineered as efficient replication-deficient and -competent expression vectors. Alphavirus vectors have frequently been used as vehicles for tumor vaccine generation. Moreover, SFV and SIN vectors have been applied for intratumoral injections in animals implanted with tumor xenografts. SIN vectors have demonstrated natural tumor targeting, which might permit systemic vector administration. Another approach for systemic delivery of SFV has been to encapsulate replication-deficient viral particles in liposomes, which can provide passive targeting to tumors and allow repeated administration without host immune responses. This approach has demonstrated safe delivery of encapsulated SFV particles to melanoma and kidney carcinoma patients in a phase I trial. Finally, the prominent neurotropism of alphaviruses make them attractive for the treatment of CNS-related diseases.
Keywords: Viral vectors; Vaccines; CNS; Cancer therapy Viral vectors; Vaccines; CNS; Cancer therapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lundstrom, K. Alphaviruses in Gene Therapy. Viruses 2009, 1, 13-25.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top