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Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
Centre d’Immunologie Marseille-Luminy, Université de la Méditerranée, Marseille, F-13288, France
INSERM, U631, Marseille, F-13288, France
CNRS, UMR6102, Marseille, F-13288, France
Faculté de Pharmacie Strasbourg, Illkirch, F-67400, France
EA Physiopathologie et Médecine Translationnelle, Laboratoire d’ImmunoGénétique Moléculaire Humaine, Faculté de Médecine, Strasbourg, F-67085, France
* Author to whom correspondence should be addressed.
Received: 13 August 2009; in revised form: 19 October 2009 / Accepted: 20 October 2009 / Published: 20 October 2009
Abstract: Host resistance to infection depends on the efficiency with which innate immune responses keep the infectious agent in check. Innate immunity encompasses components with sensing, signaling and effector properties. These elements with nonredundant functions are encoded by a set of host genes, the resistome. Here, we review our findings concerning the resistome. We have screened randomly mutagenized mice for susceptibility to a natural opportunistic pathogen, the mouse cytomegalovirus. We found that some genes with initially no obvious functions in innate immunity may be critical for host survival to infections, falling into a newly defined category of genes of the resistome.
Keywords: N-ethyl-N-nitrosourea; mutagenesis; resistome; mouse cytomegalovirus; susceptibility; innate immunity; homeostasis
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MDPI and ACS Style
Crozat, K.; Georgel, P. Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis. Viruses 2009, 1, 460-483.
Crozat K, Georgel P. Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis. Viruses. 2009; 1(3):460-483.
Crozat, Karine; Georgel, Philippe. 2009. "Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis." Viruses 1, no. 3: 460-483.