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Rotavirus Antagonism of the Innate Immune Response
AbstractRotavirus is a primary cause of severe dehydrating gastroenteritis in infants and young children. The virus is sensitive to the antiviral effects triggered by the interferon (IFN)-signaling pathway, an important component of the host cell innate immune response. To counteract these effects, rotavirus encodes a nonstructural protein (NSP1) that induces the degradation of proteins involved in regulating IFN expression, such as members of the IFN regulatory factor (IRF) family. In some instances, NSP1 also subverts IFN expression by causing the degradation of a component of the E3 ubiquitin ligase complex responsible for activating NF-κB. By antagonizing multiple components of the IFN-induction pathway, NSP1 aids viral spread and contributes to rotavirus pathogenesis.
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Arnold, M.M.; Patton, J.T. Rotavirus Antagonism of the Innate Immune Response. Viruses 2009, 1, 1035-1056.View more citation formats
Arnold MM, Patton JT. Rotavirus Antagonism of the Innate Immune Response. Viruses. 2009; 1(3):1035-1056.Chicago/Turabian Style
Arnold, Michelle M.; Patton, John T. 2009. "Rotavirus Antagonism of the Innate Immune Response." Viruses 1, no. 3: 1035-1056.