Next Article in Journal
Recent Developments in Public Health Nursing in the Americas
Next Article in Special Issue
Molecular Epidemiology for Vector Research on Leishmaniasis
Previous Article in Journal
The Impact of School Tobacco Policies on Student Smoking in Washington State, United States and Victoria, Australia
Previous Article in Special Issue
The Changing Disease-Scape in the Third Epidemiological Transition
Int. J. Environ. Res. Public Health 2010, 7(3), 711-728; doi:10.3390/ijerph7030711
Review

Usefulness of Mendelian Randomization in Observational Epidemiology

*  and
Received: 29 December 2009 / Accepted: 16 February 2010 / Published: 26 February 2010
(This article belongs to the Special Issue Advances in Epidemiology)
View Full-Text   |   Download PDF [464 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a “Mendelian randomization” approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far.
Keywords: genetic epidemiology; causality; observational studies; instrumental variables genetic epidemiology; causality; observational studies; instrumental variables
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Bochud, M.; Rousson, V. Usefulness of Mendelian Randomization in Observational Epidemiology. Int. J. Environ. Res. Public Health 2010, 7, 711-728.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert