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Int. J. Environ. Res. Public Health 2009, 6(11), 2725-2739; doi:10.3390/ijerph6112725

A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

1
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
2
Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA
3
Departments of Psychiatry, Behavioral Medicine, and Neurology Medical College of Wisconsin, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
Received: 27 August 2009 / Accepted: 17 October 2009 / Published: 27 October 2009
(This article belongs to the Special Issue Alcohol and Public Health)
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Abstract

Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. We tested the hypothesis that a history of alcohol dependence is associated with an increased incidence and severity of POCD in male patients undergoing cardiac surgery using cardiopulmonary bypass. Recent verbal and nonverbal memory and executive functions were assessed before and one week after surgery in patients with or without a history of alcohol dependence. Cognitive function was significantly reduced after cardiac surgery in patients with versus without a history of alcohol dependence. The results suggest that a history of alcohol dependence increases the incidence and severity of POCD after cardiac surgery. View Full-Text
Keywords: alcohol dependence; cardiac surgery; cardiopulmonary bypass; neurocognitive function alcohol dependence; cardiac surgery; cardiopulmonary bypass; neurocognitive function
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hudetz, J.A.; Patterson, K.M.; Byrne, A.J.; Iqbal, Z.; Gandhi, S.D.; Warltier, D.C.; Pagel, P.S. A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients. Int. J. Environ. Res. Public Health 2009, 6, 2725-2739.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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