Int. J. Environ. Res. Public Health 2009, 6(9), 2510-2525; doi:10.3390/ijerph6092510
Article

A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes

1 Mental Health Services, Ministry of Health, 2 Ben Tabai St., Jerusalem 93591, Israel 2 The Department of Substance Dependence Treatment, Ministry of Health, 20 King David St., Jerusalem 91010, Israel 3 Tirat Carmel Mental Health Center, Ministry of Health, 17 Ha'ela St., 'Tirat Carmel 30200, Israel Sha'ar Menashe Mental Health Center, Ministry of Health, Mobile Post Hefer 37806, Israel;
* Author to whom correspondence should be addressed.
Received: 13 August 2009; Accepted: 22 September 2009 / Published: 23 September 2009
(This article belongs to the Special Issue Alcohol and Public Health)
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Abstract: To examine the effect of sildenafil on erectile dysfunction (ED) and psychosocial outcomes in alcohol-dependent (AD) men, 108 men with these diagnoses were randomly assigned to either take sildenafil (50 mg) as add-on to standard treatment for AD, or the same treatment without sildenafil, for 12 weeks. Only 50 patients in sildenafil group and 51 in control group twice completed the International Index of Erectile Function (IIEF) and a battery of self-report questionnaires. IIEF scores and psychosocial functioning, self-esteem and support from friends improved only for sildenafil-treated patients (P < 0.001). The high effect sizes suggest that the observed benefits are unlikely to be a placebo effect, although their unspecific nature could not be ruled out. In men with ED associated with AD, sildenafil improves both ED and psychosocial outcomes. Further placebo-controlled clinical trial is warranted.
Keywords: alcohol dependence; erectile dysfunction; sildenafil; depression; functioning; self-esteem; social support

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MDPI and ACS Style

Ponizovsky, A.M.; Averbuch, L.; Radomislensky, I.; Grinshpoon, A. A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes. Int. J. Environ. Res. Public Health 2009, 6, 2510-2525.

AMA Style

Ponizovsky AM, Averbuch L, Radomislensky I, Grinshpoon A. A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes. International Journal of Environmental Research and Public Health. 2009; 6(9):2510-2525.

Chicago/Turabian Style

Ponizovsky, Alexander M.; Averbuch, Lev; Radomislensky, Ira; Grinshpoon, Alexander. 2009. "A Multicenter, Randomized, Open-Labeled, Parallel Group Trial of Sildenafil in Alcohol-Associated Erectile Dysfunction: The Impact on Psychosocial Outcomes." Int. J. Environ. Res. Public Health 6, no. 9: 2510-2525.

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