Evaluation of the Effects of Chronic Intoxication with Inorganic Mercury on Memory and Motor Control in Rats
Abstract
:1. Introduction
2. Methods
2.1. Ethics Statement
2.2. Animals and Experimental Groups
2.3. Behavioral Assays
2.4. Open Field
2.5. Social Recognition
2.6. Elevated T Maze (ETM) Test
2.7. Rotarod Test
2.8. Mercury Measurements
2.9. Statistical Analysis
3. Results
3.1. Chronic HgCl2 Exposure during Late Adulthood Induces Deficits on Spontaneous Locomotor Activity in Rats
3.2. Learning, Short- and Long-Term Memory Impairments Induced by Chronic HgCl2 Exposure during Late Adulthood in Rats
3.3. Chronic HgCl2 Exposure during Late Adulthood Promotes Alterations in Motor Function
3.4. Mercury Deposition Is Higher in the Cortex than Hippocampus after Chronic Intoxication during Late Life in Rats
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Teixeira, F.B.; Fernandes, R.M.; Farias-Junior, P.M.A.; Costa, N.M.M.; Fernandes, L.M.P.; Santana, L.N.S.; Silva-Junior, A.F.; Silva, M.C.F.; Maia, C.S.F.; Lima, R.R. Evaluation of the Effects of Chronic Intoxication with Inorganic Mercury on Memory and Motor Control in Rats. Int. J. Environ. Res. Public Health 2014, 11, 9171-9185. https://doi.org/10.3390/ijerph110909171
Teixeira FB, Fernandes RM, Farias-Junior PMA, Costa NMM, Fernandes LMP, Santana LNS, Silva-Junior AF, Silva MCF, Maia CSF, Lima RR. Evaluation of the Effects of Chronic Intoxication with Inorganic Mercury on Memory and Motor Control in Rats. International Journal of Environmental Research and Public Health. 2014; 11(9):9171-9185. https://doi.org/10.3390/ijerph110909171
Chicago/Turabian StyleTeixeira, Francisco B., Rafael M. Fernandes, Paulo M. A. Farias-Junior, Natacha M. M. Costa, Luanna M. P. Fernandes, Luana N. S. Santana, Ademir F. Silva-Junior, Marcia C. F. Silva, Cristiane S. F. Maia, and Rafael R. Lima. 2014. "Evaluation of the Effects of Chronic Intoxication with Inorganic Mercury on Memory and Motor Control in Rats" International Journal of Environmental Research and Public Health 11, no. 9: 9171-9185. https://doi.org/10.3390/ijerph110909171