Next Article in Journal
Evaluation of the Effects of Chronic Intoxication with Inorganic Mercury on Memory and Motor Control in Rats
Next Article in Special Issue
The Impact of Different Proportions of a Treated Effluent on the Biotransformation of Selected Micro-Contaminants in River Water Microcosms
Previous Article in Journal
Correction: Stauber, C.E., et al. Evaluation of the Impact of the Plastic BioSand Filter on Health and Drinking Water Quality in Rural Tamale, Ghana. Int. J. Environ. Res. Public Health 2012, 9, 3806–3823
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2014, 11(9), 9156-9170; doi:10.3390/ijerph110909156

A Dose-Response Relationship between Organic Mercury Exposure from Thimerosal-Containing Vaccines and Neurodevelopmental Disorders

1
Institute of Chronic Illnesses, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA
2
Department of Biology, Simpson University, 2211 College View Dr., Redding, CA 96003, USA
3
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5353 Harry Hine Blvd., Dallas, TX 75390, USA
4
CoMeD, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA
*
Author to whom correspondence should be addressed.
Received: 12 July 2014 / Revised: 7 August 2014 / Accepted: 26 August 2014 / Published: 5 September 2014
(This article belongs to the Special Issue Emerging Contaminants in the Environment)
View Full-Text   |   Download PDF [710 KB, uploaded 5 September 2014]

Abstract

A hypothesis testing case-control study evaluated concerns about the toxic effects of organic-mercury (Hg) exposure from thimerosal-containing (49.55% Hg by weight) vaccines on the risk of neurodevelopmental disorders (NDs). Automated medical records were examined to identify cases and controls enrolled from their date-of-birth (1991–2000) in the Vaccine Safety Datalink (VSD) project. ND cases were diagnosed with pervasive developmental disorder (PDD), specific developmental delay, tic disorder or hyperkinetic syndrome of childhood. In addition, putative non-thimerosal-related outcomes of febrile seizure, failure to thrive and cerebral degenerations were examined. The cumulative total dose of Hg exposure from thimerosal-containing hepatitis B vaccine (T-HBV) administered within the first six months of life was calculated. On a per microgram of organic-Hg basis, PDD (odds ratio (OR) = 1.054), specific developmental delay (OR = 1.035), tic disorder (OR = 1.034) and hyperkinetic syndrome of childhood (OR = 1.05) cases were significantly more likely than controls to receive increased organic-Hg exposure. By contrast, none of the non-thimerosal related outcomes were significantly more likely than the controls to have received increased organic-Hg exposure. Routine childhood vaccination may be an important public health tool to reduce infectious disease-associated morbidity/mortality, but the present study significantly associates organic-Hg exposure from T-HBV with an increased risk of an ND diagnosis. View Full-Text
Keywords: attention deficit; autism; ethylmercury; merthiolate; thiomersal attention deficit; autism; ethylmercury; merthiolate; thiomersal
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Geier, D.A.; Hooker, B.S.; Kern, J.K.; King, P.G.; Sykes, L.K.; Geier, M.R. A Dose-Response Relationship between Organic Mercury Exposure from Thimerosal-Containing Vaccines and Neurodevelopmental Disorders. Int. J. Environ. Res. Public Health 2014, 11, 9156-9170.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top