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Mar. Drugs 2016, 14(8), 141; doi:10.3390/md14080141

Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation

Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Department of Anesthesiology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan
Division of Natural Products, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Author to whom correspondence should be addressed.
Academic Editor: Khalid A. El Sayed
Received: 29 March 2016 / Revised: 31 May 2016 / Accepted: 7 July 2016 / Published: 26 July 2016
(This article belongs to the Special Issue Drug Design Based on Marine Natural Product Scaffolds)
View Full-Text   |   Download PDF [2072 KB, uploaded 26 July 2016]   |  


Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited to the site of inflammation contribute to the pathogenesis of multiple inflammation-associated diseases such as chronic obstructive pulmonary disease, atherosclerosis, and hepatitis. Marine organisms are a valuable source of bioactive compounds with potential for industrial and pharmaceutical application. Marine natural products that inhibit neutrophil activation could be used as drugs for the treatment of inflammatory diseases. Numerous studies investigating marine natural products have reported novel anti-inflammatory agents. Nevertheless, the detailed mechanisms underlying their actions, which could facilitate our understanding of the molecular events occurring in neutrophils, have not been reported in most of the associated research studies. Therefore, in this review, we will present marine products that inhibit neutrophil-associated inflammation. Furthermore, we will be limiting the detailed discussion to agents with well-investigated molecular targets. View Full-Text
Keywords: marine natural products; neutrophils; anti-inflammatory; reactive oxygen species; formyl peptide receptor; phospholipase marine natural products; neutrophils; anti-inflammatory; reactive oxygen species; formyl peptide receptor; phospholipase

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, C.-Y.; Tsai, Y.-F.; Chang, W.-Y.; Yang, S.-C.; Hwang, T.-L. Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation. Mar. Drugs 2016, 14, 141.

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