Special Issue "Drug Design Based on Marine Natural Product Scaffolds"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (31 July 2016)
Prof. Dr. Khalid A. El Sayed
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, Louisiana 71201, USA
Website | E-Mail
Interests: marine and plant natural products; medicinal chemistry; computer-aided drug design; discovery, optimization, and molecular mechanism of natural products-based scaffolds for the control of metastatic breast cancer
Drug design is based on optimization of a molecule to bind at a specific molecular target, usually a macromolecule, with high degree of selectivity and potency to achieve a specific therapeutic effective without any, or with minimal, off-target effects. The binding tools of the potential “drug entity” are usually unique diverse functional groups (pharmacophores). Marine natural products (MNPs) are characterized by their structural novelty, complexity, and diversity. Bioactive MNPs are capable of interacting with biological macromolecules, with high selectivity and potency. Researchers used marine secondary metabolites as molecular probes for many decades to interrogate the complex biological systems and/or utilize them as candidates to modulate pharmacologically-relevant signaling pathways underlying diseases. Seven marine-derived products have been approved as drugs by the United States Food and Drug Administration and/or European Medicines Agency to treat various diseases and others are showing outstanding success in different clinical trial phases. As a Guest Editor, I invite researchers to provide recent advances in which marine macro-and microorganisms-derived molecules are used for the discovery of novel scaffolds and pharmacophores that may inspire the design of potential drug candidates.
Prof. Dr. Khalid A. El Sayed
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- binding mode
- computer-aided drug design
- drug design
- drug discovery
- drug scaffold
- medicinal chemistry
- molecular target
- signal transduction