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Mar. Drugs 2017, 15(4), 124; doi:10.3390/md15040124

Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA
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Academic Editor: Orazio Taglialatela-Scafati
Received: 21 December 2016 / Revised: 11 April 2017 / Accepted: 18 April 2017 / Published: 22 April 2017
(This article belongs to the Special Issue Drug Design Based on Marine Natural Product Scaffolds)
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Abstract

Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity. Although marine resources provide thousands of possible peptides, only a few peptides derived from marine sources have reached the pharmaceutical market. This review focuses on some of the peptides derived from marine sources in the past ten years and gives a brief review of those that are currently in clinical trials or on the market. View Full-Text
Keywords: marine peptides; antifungal peptides; antimicrobial peptides; extraction of peptides marine peptides; antifungal peptides; antimicrobial peptides; extraction of peptides
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MDPI and ACS Style

Sable, R.; Parajuli, P.; Jois, S. Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications. Mar. Drugs 2017, 15, 124.

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