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Mar. Drugs 2016, 14(8), 43; doi:10.3390/md14080043

Preparation of Chito-Oligomers by Hydrolysis of Chitosan in the Presence of Zeolite as Adsorbent

1
Department of Chemical Engineering, Faculty of Engineering, Al-Hussein Bin Talal University, P.O. Box 20, Ma`an 71111, Jordan
2
College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia
3
Department of Basic Sciences, Zarqa College, Al-Balqa Applied University, P.O. Box 313, Zarqa 13110, Jordan
4
Department of Chemistry, Faculty of Science, Al-Hussein Bin Talal University, P.O. Box 20, Ma`an 71111, Jordan
5
Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Technology, Petra University, P.O. Box 961343, Amman 11196, Jordan
6
Research and Innovation Center (RIC), The Jordanian Pharmaceutical Manufacturing Co., P.O. Box 94, Naor 11710, Jordan
7
The Jordanian Pharmaceutical Manufacturing Co., P.O. Box 94, Naor 11710, Jordan
*
Author to whom correspondence should be addressed.
Academic Editors: Hitoshi Sashiwa and David Harding
Received: 31 December 2015 / Revised: 9 February 2016 / Accepted: 15 February 2016 / Published: 23 July 2016
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan II, 2017)
View Full-Text   |   Download PDF [1442 KB, uploaded 23 July 2016]   |  

Abstract

An increasing interest has recently been shown to use chitin/chitosan oligomers (chito-oligomers) in medicine and food fields because they are not only water-soluble, nontoxic, and biocompatible materials, but they also exhibit numerous biological properties, including antibacterial, antifungal, and antitumor activities, as well as immuno-enhancing effects on animals. Conventional depolymerization methods of chitosan to chito-oligomers are either chemical by acid-hydrolysis under harsh conditions or by enzymatic degradation. In this work, hydrolysis of chitosan to chito-oligomers has been achieved by applying adsorption-separation technique using diluted HCl in the presence of different types of zeolite as adsorbents. The chito-oligomers were retrieved from adsorbents and characterized by differential scanning calorimetry (DSC), liquid chromatography/mass spectroscopy (LC/MS), and ninhydrin test. View Full-Text
Keywords: chitosan; chito-oligomers; zeolite; depolymerization; hydrolysis chitosan; chito-oligomers; zeolite; depolymerization; hydrolysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ibrahim, K.A.; El-Eswed, B.I.; Abu-Sbeih, K.A.; Arafat, T.A.; Al Omari, M.M.H.; Darras, F.H.; Badwan, A.A. Preparation of Chito-Oligomers by Hydrolysis of Chitosan in the Presence of Zeolite as Adsorbent. Mar. Drugs 2016, 14, 43.

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