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Mar. Drugs 2016, 14(6), 116; doi:10.3390/md14060116

Synthesis and Anti-Influenza A Virus Activity of 6′-amino-6′-deoxy-glucoglycerolipids Analogs

Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, Key Laboratory of Marine Drugs of Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Academic Editor: Khalid A. El Sayed
Received: 1 April 2016 / Revised: 2 June 2016 / Accepted: 3 June 2016 / Published: 18 June 2016
(This article belongs to the Special Issue Drug Design Based on Marine Natural Product Scaffolds)
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Abstract

A series of aminoglucoglycerolipids derivatives had been synthesized, including 6′-acylamido-glucoglycerolipids 1a1f and corresponding 2′-acylamido-glucoglycerolipids 2a2c bearing different fatty acids, glucosyl diglycerides 3a3e bearing different functional groups at C-6′ and ether-linked glucoglycerolipids 4a4c with double-tailed alkyl alcohol. The anti-influenza A virus (IAV) activity was evaluated by the cytopathic effects (CPE) inhibition assay. The results indicated that the integral structure of the aminoglycoglycerolipid was essential for the inhibition of IAV in MDCK cells. Furthermore, oral administration of compound 1d was able to significantly improve survival and decrease pulmonary viral titers in IAV-infected mice, which suggested that compound 1d merited further investigation as a novel anti-IAV candidate in the future. View Full-Text
Keywords: synthesis; aminoglucoglycerolipids; anti-influenza A virus synthesis; aminoglucoglycerolipids; anti-influenza A virus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ren, L.; Zhang, J.; Ma, H.; Sun, L.; Zhang, X.; Yu, G.; Guan, H.; Wang, W.; Li, C. Synthesis and Anti-Influenza A Virus Activity of 6′-amino-6′-deoxy-glucoglycerolipids Analogs. Mar. Drugs 2016, 14, 116.

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